RiteMED Levofloxacin Dosage/Direction for Use

Patients receiving oral or intravenous (IV) levofloxacin should be well hydrated to prevent formation of highly concentrated urine. Crystalluria and cylindruria have been reported with quinolones.
Levofloxacin should be given or taken at the same time each day.
Levofloxacin Tablet: Levofloxacin tablet can be taken with or without food. Administer dose at least 2 hours before or 2 hours after antacids containing calcium, magnesium or aluminum, after sucralfate or metal cations such as iron, multivitamin preparations with zinc, or didanosine. Concomitant administration with these drugs may significantly decrease levofloxacin absorption.
Usual Recommended Dose: Orally, 500 mg or 750 mg once every 24 hours.
The dose and duration of treatment are based on the type of infection and severity of infection being treated (see table as follows).
Levofloxacin Solution for Infusion: Levofloxacin solution for infusion should only be administered by IV infusion. It is NOT for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration.
Caution: Rapid or bolus IV infusion must be avoided because it may result to hypotension.
Usual Recommended Dose: 250 mg or 500 mg administered by slow IV infusion over 60 minutes once every 24 hours. 750 mg administered by slow IV infusion over 90 minutes once every 24 hours.
The dose and duration of treatment are based on the type and severity of infection being treated (see table as follows).
As with other parenteral antibiotic therapy in general, administration of levofloxacin solution for infusion should be continued for a minimum of 48 to 72 hours after the patient has become afebrile or evidence of bacterial eradication has been obtained. It is usually possible to switch from initial IV treatment to the oral route after a few days, depending on the patient's condition and the physician's discretion.
Levofloxacin Oral or IV Dosing in Adult Patients with Normal Renal Function (creatinine clearance ≥50 mL/min): See Table 3.

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Levofloxacin Oral or IV Dosing in Adult Patients with Renal Impairment (creatinine clearance <50 mL/min): See Table 4.

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When only the serum creatinine value is available, the following formula may be used to estimate creatinine clearance. The serum creatinine should represent a steady state of renal function: See equation.

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Levofloxacin IV Dosing in Children: See Table 5.

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Or, as prescribed by a physician.